Glycologue is a simulator of glycosylation enzymes, developed by Andrew McDonald
Please choose a simulator from one of the following options
Biosynthesis of mucin-type (GalNAc-linked) O-glycans
Biosynthesis of N-linked glycans
Human-milk oligosaccharide (HMO) biosynthesis
Ganglioside (ceramide-linked) biosynthesis
[April 2022] Hydrolases simulator added. Glycan and oligosaccharides predicted by the glycosyltransferase simulators can be passed to a set of glycohydrolases for processing.
McDonald., A.G, Tipton, K.F. and Davey, G.P. (2016) A knowledge-based system for display and
prediction of O
-glycosylation network behaviour in response to enzyme knockouts.
PLoS Comp. Biol.
McDonald, A.G. and Davey, G.P. (2021) Simulating the enzymes of ganglioside biosynthesis with
Glycologue. Beilstein J. Org. Chem. 17, 739-748. [doi: 10.3762/bjoc.17.64]
McDonald A.G., Mariethoz J., Davey G.P. and Lisacek, F. (2022) In silico analysis of the human
milk oligosaccharide glycome reveals key enzymes of their biosynthesis. Sci. Rep. Jun
27;12(1):10846. doi: 10.1038/s41598-022-14260-4]
Development of the HMO simulator is supported through the
Swiss Institute of Bioformatics
grant number SNSF
Site last updated 2023-01-05