Glycologue
Glycologue is a simulator of glycosylation enzymes, developed by Andrew McDonald
https://orcid.org/0000-0003-2727-176XPlease choose a simulator from one of the following options
O-glycans | N-glycans (beta) | HMOs | Gangliosides |
Biosynthesis of mucin-type (GalNAc-linked) O-glycans | Biosynthesis of N-linked glycans | Human-milk oligosaccharide (HMO) biosynthesis | Ganglioside (ceramide-linked) biosynthesis |
News
- [April 2022] Hydrolases simulator added. Glycan and oligosaccharides predicted by the glycosyltransferase simulators can be passed to a set of glycohydrolases for processing.
Publications
McDonald., A.G, Tipton, K.F. and Davey, G.P. (2016) A knowledge-based system for display and prediction of O-glycosylation network behaviour in response to enzyme knockouts. PLoS Comp. Biol. 12(4), e1004844. [doi: 10.1371/journal.pcbi.1004844]McDonald, A.G. and Davey, G.P. (2021) Simulating the enzymes of ganglioside biosynthesis with Glycologue. Beilstein J. Org. Chem. 17, 739-748. [doi: 10.3762/bjoc.17.64]
McDonald A.G., Mariethoz J., Davey G.P. and Lisacek, F. (2022) In silico analysis of the human milk oligosaccharide glycome reveals key enzymes of their biosynthesis. Sci. Rep. Jun 27;12(1):10846. doi: 10.1038/s41598-022-14260-4]
Acknowledgments
Development of the HMO simulator is supported through the Swiss Institute of Bioformatics grant number SNSF: 31003A_179249.
