Glycologue

Glycologue is a simulator of glycosylation enzymes, developed by Andrew McDonald

Please choose a simulator from one of the following options

O-glycans	N-glycans (beta)	HMOs	Gangliosides
Biosynthesis of mucin-type (GalNAc-linked) O-glycans	Biosynthesis of N-linked glycans	Human-milk oligosaccharide (HMO) biosynthesis	Ganglioside (ceramide-linked) biosynthesis

News

[January 2024] New publication in Scientific Reports [link].
[April 2022] Hydrolases simulator added. Glycan and oligosaccharides predicted by the glycosyltransferase simulators can be passed to a set of glycohydrolases for processing.

Publications

McDonald., A.G, Tipton, K.F. and Davey, G.P. (2016) A knowledge-based system for display and prediction of O-glycosylation network behaviour in response to enzyme knockouts. PLoS Comp. Biol. 12(4), e1004844. [doi: 10.1371/journal.pcbi.1004844]

McDonald, A.G. and Davey, G.P. (2021) Simulating the enzymes of ganglioside biosynthesis with Glycologue. Beilstein J. Org. Chem. 17, 739-748. [doi: 10.3762/bjoc.17.64]

McDonald A.G., Mariethoz J., Davey G.P. and Lisacek, F. (2022) In silico analysis of the human milk oligosaccharide glycome reveals key enzymes of their biosynthesis. Sci. Rep. Jun 27;12(1):10846. doi: 10.1038/s41598-022-14260-4]

McDonald A.G. and Lisacek, F. (2024) Simulated digestions of free oligosaccharides and mucin-type O-glycans reveal a potential role for Clostridium perfringens. Sci. Rep. Jan 18;14:1649 doi: 10.1038/s41598-023-51012-4]

Acknowledgments

Development of the HMO simulator was supported through the Swiss Institute of Bioformatics grant number SNSF: 31003A_179249.