O-glycans | N-glycans (beta) | HMOs | Gangliosides |
Biosynthesis of mucin-type (GalNAc-linked) O-glycans | Biosynthesis of N-linked glycans | Human-milk oligosaccharide (HMO) biosynthesis | Ganglioside (ceramide-linked) biosynthesis |
[April 2022] Hydrolases simulator added. Glycan and oligosaccharides predicted by the glycosyltransferase simulators can be passed to a set of glycohydrolases for processing.
McDonald, A.G. and Davey, G.P. (2021) Simulating the enzymes of ganglioside biosynthesis with Glycologue. Beilstein J. Org. Chem. 17, 739-748. [doi: 10.3762/bjoc.17.64]
McDonald A.G., Mariethoz J., Davey G.P. and Lisacek, F. (2022) In silico analysis of the human milk oligosaccharide glycome reveals key enzymes of their biosynthesis. Sci. Rep. Jun 27;12(1):10846. doi: 10.1038/s41598-022-14260-4]
McDonald A.G. and Lisacek, F. (2024) Simulated digestions of free oligosaccharides and mucin-type O-glycans reveal a potential role for Clostridium perfringens. Sci. Rep. Jan 18;14:1649 doi: 10.1038/s41598-023-51012-4]