Iterations: | – 1 + |
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Style: SNFG | UOXF |
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GlcNAc limit: | – 4 + |
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GlycoForm
Enter or
import initial Human milk oligosaccharide
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Properties |
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Monoisotopic mass: | 2767.97622 g/mol |
Average mass: | 2769.492 g/mol |
Composition: | H7N5S2 |
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Milk oligosaccharide |
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Download image as: |
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Structure identifier: [[L4Y3L4Y6][[S3L4Y6][S6L4Y3]L4Y3]L4G]
IUPAC condensed name: [[Galb1-4GlcNAcb1-3Galb1-4GlcNAcb1-6][[Neu5Aca2-3Galb1-4GlcNAcb1-6][Neu5Aca2-6Galb1-4GlcNAcb1-3]Galb1-4GlcNAcb1-3]Galb1-4Glcb1-]
Linear Code: (((NNa6Ab4GNb3)(NNa3Ab4GNb6)Ab4GNb3)(Ab4GNb3Ab4GNb6)Ab4Gb)
RES
1b:x-dglc-HEX-1:5
2b:b-dgal-HEX-1:5
3b:b-dglc-HEX-1:5
4s:n-acetyl
5b:b-dgal-HEX-1:5
6b:b-dglc-HEX-1:5
7s:n-acetyl
8b:b-dgal-HEX-1:5
9b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
10s:n-acetyl
11b:b-dglc-HEX-1:5
12s:n-acetyl
13b:b-dgal-HEX-1:5
14b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
15s:n-acetyl
16b:b-dglc-HEX-1:5
17s:n-acetyl
18b:b-dgal-HEX-1:5
19b:b-dglc-HEX-1:5
20s:n-acetyl
21b:b-dgal-HEX-1:5
LIN
1:1o(4+1)2d
2:2o(3+1)3d
3:3d(2+1)4n
4:3o(4+1)5d
5:5o(3+1)6d
6:6d(2+1)7n
7:6o(4+1)8d
8:8o(6+2)9d
9:9d(5+1)10n
10:5o(6+1)11d
11:11d(2+1)12n
12:11o(4+1)13d
13:13o(3+2)14d
14:14d(5+1)15n
15:2o(6+1)16d
16:16d(2+1)17n
17:16o(4+1)18d
18:18o(3+1)19d
19:19d(2+1)20n
20:19o(4+1)21d
Instructions
Enter a glycan into the text box as either an IUPAC name, or a structure identifier based on single-letter codes for monosaccharides,
according to the table below. Click the
Draw button to draw the structure; (optionally) click
Select to choose a knockout
set of enzymes to act on this structure; click
React to submit the current structure to Glycologue as a
substrate of the enzymes of human-milk oligosaccharide (HMO) biosynthesis. Click
Predict to run the enzyme simulator in reverse,
to discover a minimal set of enzymes required to produce the current glycan.
(Example) Enter [Neu5Aca2-3Galb1-3[Neu5Aca2-6]GlcNAcb1-3Galb1-4Glcb1-]
or
[S3L3[S6]Y3L4G]
The anomericity of monosaccharides is implicit, based on the enzymes of human-milk oligosaccharide (HMO) biosynthesis: L and Y are β-linked while f, S and V are assumed to be α-linked.
This can be overridden by placing a or b after the sugar symbol, thus La3 would draw an α1,3-linked galactose.
The size of networks produced in simulations can be limited by decreasing the maximum number of GlcNAc residues per glycan using the Control panel. The default value is set to 4.
Symbol key
Letter | Symbol | IUPAC Symbol | Definition | Default anomer |
f |
![](images/svg/f-uoxf.svg) |
Fuc |
L-Fucose |
α |
G |
![](images/svg/G-uoxf.svg) |
Glc |
D-Glucose |
β |
K |
![](images/svg/K-uoxf.svg) |
Kdn |
2-Keto-3-deoxy-D-glycero-D-galacto-nononic acid |
α |
L |
![](images/svg/L-uoxf.svg) |
Gal |
D-Galactose |
β |
M |
![](images/svg/M-uoxf.svg) |
Man |
D-Mannose |
α |
N |
![](images/svg/N-uoxf.svg) |
Neu5Gc |
N-Glycolylneuraminic acid |
α |
S |
![](images/svg/S-uoxf.svg) |
Neu5Ac |
N-Acetylneuraminic acid (sialic acid) |
α |
u |
![](images/svg/u-uoxf.svg) |
IdoA |
L-Iduronic acid |
α |
V |
![](images/svg/V-uoxf.svg) |
GalNAc |
N-Acetyl-D-galactosamine |
α |
X |
![](images/svg/X-uoxf.svg) |
Xyl |
D-Xylose |
β |
Y |
![](images/svg/Y-uoxf.svg) |
GlcNAc |
N-Acetyl-D-glucosamine |
β |
Z |
![](images/svg/Z-uoxf.svg) |
GlcA |
D-Glucuronic acid |
β |
s |
![](images/svg/sulf-uoxf.svg) |
-HSO3 |
Sulfate |
- |
a,b |
![](images/svg/ab-uoxf.svg) |
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Anomeric linkage type |
- |